Friday, June 10, 2011

Sexual transmission of XMRV

Sexual transmission of XMRV:a potential infection route

Prachi Sharma, Kenneth Rogers, Suganthi Suppiah, Ross Ross Molinaro
Ross J. Molinaro, Nattawat Onlamoon, J. Hackett Jr., G. Schochetman,
Eric A. Klein, Robert Silverman, and F. Villinger

Received 27 April 2011; Accepted 25 May 2011

Although XMRV dissemination in humans is a matter of debate, the
prostate of select patients seem to harbor XMRV, which raises
questions about its potential route of transmission. We established a
model of infection in rhesus macaques inoculated with XMRV. In spite
of the intravenous inoculation, all infected macaques exhibited
readily detectable XMRV signal in the reproductive tract of all 4
males and 1 female during both acute and chronic infection stages.
XMRV showed explosive growth in the acini of prostate during acute but
not chronic infection. In seminal vesicles, epididymis and testes,
XMRV protein production was detected throughout infection in
interstitial or epithelial cells. In the female monkey, epithelial
cells in the cervix and vagina were also positive for XMRV gag. The
ready detection of XMRV in the reproductive tract of male and female
macaques infected intravenously, suggests the potential for sexual
transmission for XMRV.
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One more thing to "thank" my ex for?

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