Saturday, February 24, 2018

ME and Eye



Source: University of Leicester
Date: September 2017. Online: February 15, 2018
URL: https://lra.le.ac.uk/handle/2381/41228
https://lra.le.ac.uk/bitstream/2381/41228/1/2018AhmedNSMphil.pdf


Ophthalmic correlates of Myalgic Encephalomyelitis (ME)/Chronic
Fatigue Syndrome (CFS)
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Nadia Sultana Ahmed
- College of Life Sciences, Dept. of Neuroscience, Psychology and
Behaviour, University of Leicester


Abstract

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a
chronic, debilitating disorder. With the exception of disabling
fatigue, there are few definitive clinical features of the condition.
As a consequence, patients often have difficulty gaining an
appropriate diagnosis. As such, identifying distinct clinical features
of ME/CFS is an important issue. One under researched area of
ME/CFSassociated symptoms concerns problems related to vision. People
with ME/CFS consistently report a range of symptoms related to the
quality of their vision including pain in the eyes, hypersensitivity
to light, difficulty focusing on images, slow eye movements, and
difficulty tracking object movement. However, there has been little
attempt to verify patients' self-reports using objective methods. The
purpose of the experiments presented in this thesis was to determine
the effects of ME/CFS on: (i) performance on a range of tests of
visual sensitivity and (ii) the morphology of the retina. Compared to
controls, the ME/CFS group exhibited reduced accommodation, larger
pupil diameters, reduced colour discrimination and poorer contrast
sensitivity towards lower spatial frequencies. Thinning in the
photoreceptor layers of the retina (the Outer Segment & the Outer
Nuclear layer) was also apparent. These findings support the claims of
people with ME/CFS that they experience problems related to their
vision and its function. They also represent a potential marker of
ME/CFS that may aid in its diagnosis.

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(c) 2018 University of Leicester

1 comment:

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