Friday, May 15, 2015
100: No symptoms with exercise. Normal overall activity. Able to work or do
house/home work full time with no difficulty.
90: No symptoms at rest. Mild symptoms with physical activity. Normal
overall activity level. Able to work full time without difficulty.
80: Mild symptoms at rest. Symptoms worsened by exertion. Minimal activity
restriction needed for activities requiring exertion only. Able to work
full time with difficulty in jobs requiring exertion.
70: Mild symptoms at rest. Some daily activity limitation clearly noted.
Overall functioning close to 90% of expected except for activities requiring
exertion. Able to work/do housework full time with difficulty. Needs to
rest in day.
60: Mild to moderate symptoms at rest. Daily activity limitation clearly
noted. Overall functioning 70% to 90%. Unable to work full time in jobs
requiring physical labor (including just standing), but able to work full time
in light activity (sitting) if hours are flexible.
50: Moderate symptoms at rest. Moderate to severe symptoms with exercise or
activity; overall activity level reduced to 70% of expected. Unable to
perform strenuous duties, but able to perform light duty or deskwork 4 - 5
hours a day, but requires rest periods. Has to rest/sleep 1-2 hours daily.
40: Moderate symptoms at rest. Moderate to severe symptoms with exercise or
activity. Overall activity level reduced to 50-70% of expected. Able to go
out once or twice a week. Unable to perform strenuous duties. Able to work
sitting down at home 3-4 hours a day, but requires rest periods.
30: Moderate to severe symptoms at rest. Severe symptoms with any exercise.
Overall activity level reduced to 50% of expected. Usually confined to
house. Unable to perform any strenuous tasks. Able to perform deskwork 2-3
hours a day, but requires rest periods.
20: Moderate to severe symptoms at rest. Unable to perform strenuous
activity. Overall activity 30-50% of expected. Unable to leave house except
rarely. Confined to bed most of day. Unable to concentrate for more than 1 hour
10: Severe symptoms at rest. Bed ridden the majority of the time. No travel
outside of the house. Marked cognitive symptoms preventing concentration.
0: Severe symptoms on a continuous basis. Bed ridden constantly, unable to
care for self.
These immune signatures represent the first robust physical evidence that ME/CFS is a biological illness as opposed to a psychological disorder, and the first evidence that the disease has distinct stages. Results appear online in the new American Association for the Advancement of Science journal, Science Advances.
With funding to support studies of immune and infectious mechanisms of disease from the Chronic Fatigue Initiative of the Hutchins Family Foundation, the researchers used immunoassay testing methods to determine the levels of 51 immune biomarkers in blood plasma samples collected through two multicenter studies that represented a total of 298 ME/CFS patients and 348 healthy controls. They found specific patterns in patients who had the disease three years or less that were not present in controls or in patients who had the disease for more than three years.