Does oral Coenzyme Q10 plus NADH supplementation improve fatigue and
biochemical parameters in Chronic Fatigue Syndrome?
Dr. JESUS CASTRO-MARRERO, Ph.D., Prof. Mario D. Cordero, Dr. Maria
Jose Segundo, Naia Saez-Francas, Dr. Natalia Calvo, Dr. Lourdes
Román-Malo, Luisa Aliste, Prof. Tomas Fernandez de Sevilla, Dr. Jose
Chronic Fatigue Syndrome (CFS) is a chronic and extremely debilitating
illness characterized by prolonged fatigue and multiple symptoms with
unknown cause, diagnostic test, or universally effective treatment.
Inflammation, oxidative stress, mitochondrial dysfunction, and CoQ10
deficiency have been well documented in CFS. We conducted an 8-weeks
randomized, double-blind, placebo-controlled trial to evaluate the
benefits of oral CoQ10 (200 mg/day) plus NADH (20 mg/day)
supplementation on fatigue and biochemical parameters in 73 Spanish
CFS patients. This study was registered in ClinicalTrials.gov
(NCT02063126). A significant improvement of fatigue showing a
reduction in FIS total score (p< 0.05) was reported in treated group
vs. placebo. In addition, a recovery of the biochemical parameters was
also reported. NAD+/NADH (p< 0.001), CoQ10 (p< 0.05), ATP (p< 0.05)
and citrate synthase (p< 0.05) were significantly higher and
lipoperoxides (p< 0.05) were significantly lower in blood mononuclear
cells (BMCs) of the treated group. These observations lead to the
hypothesis that the oral CoQ10 plus NADH supplementation could confers
potential therapeutic benefits on fatigue and biochemical parameters
in CFS. Larger sample trials are warranted to confirm these findings.