Tuesday, July 1, 2014

Proof of Abnormal Response to Exercise in CFS


Exerc Immunol Rev. 2014;20:94-116.
Altered immune response to exercise in patients with chronic fatigue
syndrome/myalgic encephalomyelitis: a systematic literature review.
Nijs J, Nees A, Paul L, De Kooning M, Ickmans K, Meeus M, Van Oosterwijck J.


An increasing number of studies have examined how the immune system of
patients with Chronic Fatigue Syndrome (CFS), or myalgic
encephalomyelitis, responds to exercise. The objective of the present
study was to systematically review the scientific literature
addressing exercise-induced immunological changes in CFS patients
compared to healthy control subjects. A systematic literature search
was conducted in the PubMed and Web of science databases using
different keyword combinations. We included 23 case control studies
that examined whether CFS patients, compared to healthy sedentary
controls, have a different immune response to exercise. The included
articles were evaluated on their methodological quality. Compared to
the normal response of the immune system to exercise as seen in
healthy subjects, patients with CFS have a more pronounced response in
the complement system (i.e. C4a split product levels), oxidative
stress system (i.e. enhanced oxidative stress combined with a delayed
and reduced anti-oxidant response), and an alteration in the immune
cells' gene expression profile (increases in post-exercise
interleukin-10 and toll-like receptor 4 gene expression), but not in
circulating pro- or anti-inflammatory cytokines. Many of these immune
changes relate to post-exertional malaise in CFS, a major
characteristic of the illness.
The literature review provides level B
evidence for an altered immune response to exercise in patients with

PMID: 24974723 [PubMed - in process]

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