Thursday, March 27, 2014

Neuroinflammation in CFS

J Nucl Med. 2014 Mar 24. [Epub ahead of print]

Neuroinflammation in Patients with
Chronic Fatigue Syndrome/Myalgic
Encephalomyelitis: An
11C-(R)-PK11195 PET Study.

Nakatomi Y1, Mizuno K, Ishii A, Wada Y,
Tanaka M, Tazawa S, Onoe K, Fukuda S,
Kawabe J, Takahashi K, Kataoka Y,
Shiomi S, Yamaguti K, Inaba M,
Kuratsune H, Watanabe Y.


Abstract

Chronic fatigue syndrome/myalgic encephalomyelitis
(CFS/ME) is a disease characterized by chronic,
profound, disabling, and unexplained fatigue.

Although it is hypothesized that brain inflammation
is involved in the pathophysiology of CFS/ME, there
is no direct evidence of neuroinflammation in
patients with CFS/ME.

Activation of microglia or astrocytes is related to
neuroinflammation.
11C-(R)-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline-carboxamide
(11C-(R)-PK11195) is a ligand of PET for a
translocator protein that is expressed by activated
microglia or astrocytes.

We used 11C-(R)-PK11195 and PET to investigate
the existence of neuroinflammation in CFS/ME
patients.

METHODS:

Nine CFS/ME patients and 10 healthy controls
underwent 11C-(R)-PK11195 PET and completed
questionnaires about fatigue, fatigue sensation,
cognitive impairments, pain, and depression.

To measure the density of translocator protein,
nondisplaceable binding potential (BPND) values
were determined using linear graphical analysis with
the cerebellum as a reference region.

RESULTS:

The BPND values of 11C-(R)-PK11195 in the
cingulate cortex, hippocampus, amygdala, thalamus,
midbrain, and pons were 45%-199% higher in
CFS/ME patients than in healthy controls.

In CFS/ME patients, the BPND values of
11C-(R)-PK11195 in the amygdala, thalamus, and
midbrain positively correlated with cognitive
impairment score, the BPND values in the cingulate
cortex and thalamus positively correlated with pain
score, and the BPND value in the hippocampus
positively correlated with depression score.

CONCLUSION:

Neuroinflammation is present in widespread brain
areas in CFS/ME patients and was associated with
the severity of neuropsychologic symptoms.

Evaluation of neuroinflammation in CFS/ME patients
may be essential for understanding the core
pathophysiology and for developing objective
diagnostic criteria and effective medical treatments.


KEYWORDS:

11C-(R)-PK11195, chronic fatigue syndrome (CFS),
myalgic encephalomyelitis (ME), neuroinflammation,
positron emission tomography (PET)

PMID: 24665088 [PubMed - as supplied by publisher]

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