Wednesday, March 26, 2014

Conference: Translating Science into Clinical Care -- Lipkin

Lipkin notes that Montoya lets the data drive the research, rather than hypothesis.  Some researchers will tweak the data to prove what they want to prove, but not Montoya.  "We have people who are wedded to organisms", but Montoya is correct, to let the data lead.
 
Even when research fails, we ARE excluding causes.  Just by doing that we're getting closer to what it might be.  Every time we test and DON'T find something, it can be just as important as what we do find.
 
The cost of human genome sequencing is coming down.  It's now $1800 / 1400 euros.  Which means they're doing more of it.
 
Central nervous system auto-antibodies / bacterium-induced mental illness
Sometimes what looks like an infection is not -- it can be an "intoxication" that results in an autoimmune disorder.  He noted that in a slaughterhouse, the workers who were exposed to myelin had an autoimmune response.
 
Some people respond to carbohydrate reduction, some don't -- different body chemistry means different food reactions.  So just because your friend had success with dietary changes does not mean you will.
 
Absence of evidence of Borna virus in Swedish patients with CFS -- J.Neurobiology 1999
retrovirus 85%, annellovirus 75%
 
IL17 and IFNy in patients sick less than 3 years, higher; but Eotaxin in all patients
 
In the Q&A, Lipkin stopped seeing patients in 2001; he's now mostly the spokesman for the researchers.  But, in response to a specific question, "I'm pretty good on neuropathy"
 
70% of encephalitis is untestable -- only a post-mortem brain biopsy will find it
 
There is zero evidence that XMRV infects humans
 
There is 5x the risk of autism if the mother has a fever in early pregnancy
 
If there were a single agent, someone might have found it by now.
 
We need to look in other places.
 
The agent need not be replicating -- it could be something that acts one time and serves as a trigger for an autoimmune response.
 
 
 

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