Saturday, March 22, 2014

Ask Dr. Komaroff

Ask Dr. K: Coping with chronic fatigue syndrome
Anthony L. Komaroff, M.D. Ask Dr. K
Posted:   03/21/2014 11:40:14 AM PDT | Updated:   about 6 hours ago

Dear Dr. K: I have CFS. What is the latest information about the
condition, particularly treatments?

Dear Reader: For readers who are not familiar with the condition, CFS
stands for chronic fatigue syndrome. Fatigue is a universal human
experience. In our increasingly pressured and fast-paced lives, many
people feel tired a lot of the time. In fact, fatigue is one of the
most common reasons people visit their doctor. Yet very few people
with fatigue are suffering from CFS. It is relatively uncommon,
affecting about 4 to 8 out of every thousand adults in the U.S., and a
small fraction of teenagers and younger children.

People with CFS experience ongoing, severe, debilitating fatigue that
is not relieved by rest. Other symptoms include: Impaired memory or
concentration, sore throat, swollen glands, muscle pain, pain in
multiple joints, headaches, and exhaustion following physical

We don't know what causes CFS. People with CFS are more likely than
healthy people -- and people with other fatigue-causing diseases -- to
have various abnormalities.

Many have chronic activation of different parts of the immune system. Many have problems with their cells making enough energy. Many have biochemical abnormalities called oxidative and nitrosative stress.

Then there are problems involving the brain that have been found, thanks to brain imaging techniques (MRI, SPECT and PET). Brain hormones often respond differently to challenges. Electrical brain wave studies often show differences. The autonomic nervous system, the part of the brain that controls basic body functions -- such as heart rate, blood pressure and body temperature -- often does not work properly. But the abnormalities are not seen in all patients with CFS, and they come and go. What is causing these abnormalities remains uncertain.

A combination of the following strategies may help manage your symptoms:

· Set priorities. Make a list of things you want to have more energy
to do. Eliminate as many nonessential activities as you can. But be
careful to guard against becoming too passive.

· Exercise. Begin an exercise program in which you gradually increase
your activity level. This can effectively reduce the severity of your

· Cognitive behavioral therapy (CBT). CBT is a type of psychotherapy.
It helps you identify and change negative thoughts and behaviors. CBT
can reduce symptoms.

· Tricyclic antidepressants. Low doses of this type of antidepressant
may improve the quality of your sleep, reduce pain, and increase

· Other medications. Nonsteroidal anti-inflammatory drugs (NSAIDs) and
acetaminophen (Tylenol) can help relieve headaches, joint pain and
muscle pain. Fish oil capsules (3,000 mg per day) may also help reduce
CFS symptoms.

There are also several experimental treatments in development. These
include drugs to treat abnormalities of the autonomic nervous system,
to quiet activated parts of the immune system, and antiviral drugs
(for people with certain active viral infections).

I am impressed by the progress made in understanding CFS over the past
25 years. It was made possible by research conducted and supported by
the National Institutes of Health, Centers for Disease Control and
Prevention, and private foundations. Still, we have a lot more to

Dr. Komaroff is a physician and professor at Harvard Medical School.
See his website to send questions and get additional information: 
* * *
If you're signing up for CBT, make sure your therapist is going to deal with your grief over losing your former lifestyle, rather than persuading you to overdo yourself right into bed with assertions that you're not really sick.

1 comment:


Dr. Anthony L. Komaroff MD (Harvard Medical School):

"Overview of HHV6 in CNS Disease. The Evidence as seen by a Clinical Epidemiologist"

14-minute presentation -->