Wednesday, March 26, 2014

2014 IACFS/ME Conference -- Jarred Younger on fibro

"I believe there is significant overlap between FM and CFS"
 
future research and treatment
 
BAD NEWS: 25% improve over time, 39% get worse
 
GOOD NEWS: increased scientific interest -- there were 600 papers on fibro last year
 
Central nervous system? or muscles? brain? spinal cord?
Central Sensitivity Syndrome = brain and spinal cord
 
pain is our alarm system, and fibro is a broken alarm
 
the flu produces a sickness response -- your immune system does that to you on purpose
microglia protect us from everything -- they change shape, pro-inflammatory chemicals make neurons make you feel bad -- they function to make you rest so your body can divert all resources to fight infections
 
what if the microglia dysregulate? get stuck "on"
 
similarity between fibromyalgia and sickness response hints that they're related
 
primed, hair trigger, easy to activate, reaction to something that's not supposed to
 
we can't directly test this, can't get into the brain
 
CSS? undiagnosed other? SFPN? CSF leak? Vitamin D deficiency?
 
N.B. -- once you get a CFS/fibro diagnosis, all other testing stops
 
SFPN -- starts more distant from the heart, and treatment differs from fibro
 
pain worse, leptin rises -- chicken/egg
 
brain imaging -- some regions of brain are changing -- pain and emotion areas are shrinking -- this may be an adaptation rather than the cause
 
PET -- tracer is soaked up by activated microglia -- this has been tested in MS
 
brain temperature
 
TREATMENTS:
low dose naltrexone -- prevents microglia from reacting as strongly -- 50%+ improve
fluorocitrate
minocycline
ibudilast (AV 411)
dextromethorphan
3-hydroxymorphinan
 
some herbs suppress microglia, but this has not been tested in fibromyalgia
 
 
 
 

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