Thursday, April 11, 2013

Mycotoxins and CFS

NOTE: Correlation and causation are not the same thing, but it has been
hypothesized that many different pathogens can trigger a disease or
diseases with core symptoms in common. Pathogens may also exacerbate
existing disease or work together.

Toxins 2013, 5, 605-617; doi:10.3390/toxins5040605
toxins ISSN 2072-6651

Detection of Mycotoxins in Patients with Chronic Fatigue Syndrome

Joseph H. Brewer, Jack D. Thrasher , David C. Straus , Roberta A. Madison 4
and Dennis Hooper

Abstract: Over the past 20 years, exposure to mycotoxin producing mold has
recognized as a significant health risk. Scientific literature has
demonstrated mycotoxins as
possible causes of human disease in water-damaged buildings (WDB).

This study was conducted to determine if selected mycotoxins could be
identified in human urine from patients suffering from chronic fatigue
syndrome (CFS). Patients (n = 112) with a prior
diagnosis of CFS were evaluated for mold exposure and the presence of
mycotoxins in
their urine.

Urine was tested for aflatoxins (AT), ochratoxin A (OTA) and macrocyclic
trichothecenes (MT) using Enzyme Linked Immunosorbent Assays (ELISA). Urine
specimens from 104 of 112 patients (93%) were positive for at least one
mycotoxin (one in
the equivocal range).

Almost 30% of the cases had more than one mycotoxin present. OTA
was the most prevalent mycotoxin detected (83%) with MT as the next most
(44%). Exposure histories indicated current and/or past exposure to WDB in
over 90% of

Environmental testing was performed in the WDB from a subset of these
This testing revealed the presence of potentially mycotoxin producing mold
species and
mycotoxins in the environment of the WDB. Prior testing in a healthy
control population A hypothesis of possible mitochondrial damage in CFS
is presented following review of the literature. The mitochondrial
dysfunction may be triggered and accentuated by exposure
to mycotoxins.

OPEN ACCESS The full study can be read here:

Received: 18 March 2013; in revised form: 1 April 2013 / Accepted: 3 April
2013 /
Published: 11 April 2013

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