exacerbated by post exertional malaise, medication side-effects,
and/or co-occurring thyroid issues. These patients and/or others may
have increased inflammation as measured by CRP as well.
For the Overweight, Some Carbs Better than Others
By Todd Neale, Senior Staff Writer, MedPage Today
Published: January 13, 2012
Reviewed by Zalman S. Agus, MD; Emeritus Professor
University of Pennsylvania School of Medicine.
This randomized study shows that a low glycemic diet reduced
high-sensitivity CRP and tended to increase adiponectin serum
concentrations in participants with high body fat mass.
A diet with a low-glycemic load may have benefits for overweight and
obese individuals who are otherwise healthy, a randomized, crossover
Compared with a high-glycemic load diet, one with a low-glycemic load
was associated with a significant reduction in high-sensitivity
C-reactive protein (P=0.02) in people with a body mass index of 28 to
40 kg/m2, according to Marian Neuhouser, PhD, of the Fred Hutchinson
Cancer Research Center in Seattle, and colleagues.
There was also a trend toward an increase in adiponectin (P=0.06), a
beneficial hormone that increases insulin sensitivity and fatty acid
oxidation, the researchers reported online in the Journal of
Foods with low glycemic loads include various fruits and vegetables,
cheese, milk, and yogurt.
Participants' weight remained steady throughout the study.
"Although weight loss and maintenance of energy balance should remain
one of the critical components of any lifestyle intervention for the
overweight and obese, the results from this study suggest that diet
composition, particularly carbohydrate quality, plays a key role,"
Neuhouser and colleagues wrote.
"Adhering to a low-glycemic load diet may help individuals at risk of
obesity-related metabolic dysfunction improve their overall health."
High-glycemic load diets lead to rapid increases in blood glucose and
insulin concentrations, whereas low-glycemic load diets result in less
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