Thursday, November 8, 2012

Significant neuroanatomical changes occur in CFS

British Journal of Radiology 2011, doi:10.1259/bjr/93889091


Full Text (PDF): http://bjr.birjournals.org/cgi/reprint/93889091v1


Regional grey and white matter volumetric
changes in myalgic encephalomyelitis
(chronic fatigue syndrome): a voxel-based
morphometry 3-T MRI study

B K Puri, PhD, FRCPsych1, P M Jakeman, MSc, PhD2,
M Agour, MB, MRCPsych3, K D R Gunatilake, MD,
MRCPsych4, K A C Fernando, MBBS, MRCPsych5, A I
Gurusinghe, MBBS, PGDPsych6, I H Treasaden, MRCS,
FRCPsych7, A D Waldman, PhD, MRCP1,8 and P
Gishen, DMRD, FRCR1

1 Department of Imaging, Hammersmith Hospital, London,
UK 2 Department of Physical Education and Sport
Sciences, University of Limerick, Republic of Ireland 3
University of Hertfordshire, and Care Principles, Rose
Lodge, Langley, West Midlands, UK 4 The Ridge Hill
Centre, Dudley, UK 5 Brooklands Hospital, Birmingham,
West Midlands, UK 6 Broadmoor Hospital, Berkshire, UK
7 Three Bridges Unit, WLMHT, Middlesex, UK 8 National
Hospital for Neurology and Neurosurgery, Queen Square,
London, UK


Objective:

It is not established whether myalgic
encephalomyelitis/chronic fatigue syndrome (CFS) is
associated with structural brain changes. The aim of this
study was to investigate this by conducting the largest
voxel-based morphometry study to date in CFS.

Methods:
High-resolution structural 3-T cerebral MRI scanning was
carried out in 26 CFS patients and 26 age- and
gender-matched healthy volunteers. Voxel-wise
generalised linear modelling was applied to the processed
MR data using permutation-based non-parametric testing,
forming clusters at t > 2.3 and testing clusters for
significance at p < 0.05, corrected for multiple
comparisons across space.

Results:

Significant voxels (p < 0.05, corrected for multiple
comparisons) depicting reduced grey matter volume in the
CFS group were noted in the occipital lobes (right and left
occipital poles; left lateral occipital cortex, superior
division; and left supracalcrine cortex), the right angular
gyrus and the posterior division of the left
parahippocampal gyrus. Significant voxels (p < 0.05,
corrected for multiple comparisons) depicting reduced
white matter volume in the CFS group were also noted in
the left occipital lobe.

Conclusion:

These data support the hypothesis that significant
neuroanatomical changes occur in CFS, and are
consistent with the complaint of impaired memory that is
common in this illness; they also suggest that subtle
abnormalities in visual processing, and discrepancies
between intended actions and consequent movements,
may occur in CFS.

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