Thursday, November 8, 2012

CFS and Impaired Cardiac Function -- MRI tagging

J Intern Med. 2011 Jul 27. doi:
[Epub ahead of print]

Impaired Cardiac Function in
Chronic Fatigue Syndrome
measured using Magnetic
Resonance Cardiac Tagging.

Hollingsworth KG, Hodgson T,
Macgowan GA, Blamire AM, Newton JL.

Newcastle Magnetic
Resonance Centre, Institute of
Cellular Medicine, Newcastle
University, Campus for Ageing
and Vitality, NE4 5PL, UK
Institute for Ageing and
Health, Newcastle University,
Campus for Ageing and
Vitality, NE4 5PL, UK

Department of Cardiology,
Freeman Hospital, Newcastle
upon Tyne, NE7 7DN and
Institute of Human Genetics,
Newcastle University, NE2



Impaired cardiac function has
been confirmed in patients
with chronic fatigue syndrome

Magnetic resonance cardiac
tagging is a novel technique
that assesses myocardial wall
function in vivo.

We hypothesized that CFS
patients may have impaired
development and release of
myocardial torsion and strain.


Cardiac morphology and
function was assessed using
magnetic resonance imaging
and cardiac tagging
methodology in 12 CFS
(Fukuda) and 10 matched


Compared to controls the CFS
group had substantially
reduced LV mass (reduced by
23%), end diastolic volume
(30%), stroke volume (29%),
and cardiac output (25%).

Residual torsion at 150% of
the end-systolic time was
found to be significantly
higher in the CFS patients
(5.3±1.6(o) ) compared to the
control group (1.7±0.7(o),

End diastolic volume index
correlated negatively with
both torsion to endocardial
strain ratio (TSR) (r =-0.65,
p=0.02) and the residual
torsion at 150% end systolic
time (r=-0.76, p=0.004), so
decreased end diastolic
volume is associated with
raised TSR and torsion
persisting longer into

Reduced end diastolic volume
index also correlated
significantly with increased
radial thickening (r=-0.65,
p=0.03) and impaired
diastolic function represented
by the ratio of early to late
ventricular filling velocity (E/A
ratio, r=0.71, p=0.009) and
early filling percentage
(r=0.73, p=0.008).


CFS patients have markedly reduced cardiac mass and
blood pool volumes, particularly end diastolic volume:
this results in significant impairments in stroke volume and cardiac output compared to controls.

The CFS group appeared to have a delay in the release of torsion.

Copyright © 2011 The
Association for the
Publication of the Journal of
Internal Medicine.

PMID: 21793948 [PubMed -
as supplied by publisher]

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