Tuesday, June 26, 2012

Biological underpinnings of commonalities in depression, somatization, and CFS

Note: Tryptophan is the key ingredient in making serotonin; without
it, serotonin won't be produced.

The issue with connecting somatization with these pathways is that
somatization is a concept based in many cases on proving a negative.
There is currently no objective means of proving the concept exists
thus connections are assumed.  As always the cautions regarding
definitions used are key.

Med Hypotheses. 2012 Jun;78(6):752-6. Epub 2012 Mar 23.

Biological underpinnings of the commonalities in depression,
somatization, and Chronic Fatigue Syndrome.

Anderson G, Maes M, Berk M.
CRC, Rm 30, 57 Laurel St., Glasgow, G11 7QT Scotland, United Kingdom.


Somatization is a multisomatoform disorder characterized by medically
unexplained, functional or psychosomatic symptoms. Similar somatic
symptoms are key components of depression and Myalgic
Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

This paper reviews the evidence that such symptoms are organically
based. We use the term "physio-somatic" to describe these symptoms.

Inflammation, cell-mediated immune (CMI) activation and alterations in
the tryptophan catabolite (TRYCAT) pathway are associated with the
physio-somatic symptoms of depression, ME/CFS and/or somatization.
Proinflammatory cytokines, decreased tryptophan and aberrations in
TRYCATs may cause physio-somatic symptoms, such as fatigue, autonomic symptoms, hyperalgesia and somatic presentations.


The data suggest co-ordinated and interacting biological pathways
driving the occurrence of physio-somatic symptoms across these three
disorders, giving a biologically validated "pathway phenotype".

These data have far-reaching implications for DSM-IV diagnostic
conceptualizations of somatization (and ME/CFS) suggesting the
presence of an emerging organic explanation.

Future research should focus on the role of immune regulation, and
co-ordination, of neuronal activity and, through larger data sets,
ultimately creating new, biologically validated classification rules.
These data have implications for the development of novel therapies
utilizing these insights, buttressing the role of psychotherapy in
psychosomatic presentations.

Copyright © 2012 Elsevier Ltd. All rights reserved.

Additional research in this area; http://www.ncbi.nlm.nih.gov/pubmed/22166399
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I had great improvement when I started to take 5HTP (tryptophan).

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