Monday, October 17, 2011

Immunological Abnormalities in CFS

http://www.translational-medicine.com/content/9/1/81
fulltext- http://www.translational-medicine.com/content/pdf/1479-5876-9-81.pdf

Immunological abnormalities as potential biomarkers in Chronic Fatigue
Syndrome/ Myalgic Encephalomyelitis
Ekua W Brenu , Mieke L van Driel , Don R Staines , Kevin J Ashton ,
Sandra B Ramos , James Keane , Nancy G Klimas  and Sonya M
Marshall-Gradisnik
Journal of Translational Medicine 2011, 9:81doi:10.1186/1479-5876-9-81


Published: 28 May 2011

Abstract (provisional)

Background
Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is
characterized by severe prolonged fatigue, and decreases in cognition
and other physiological functions, resulting in severe loss of quality
of life, difficult clinical management and high costs to the health
care system. To date there is no proven pathomechanism to
satisfactorily explain this disorder. Studies have identified
abnormalities in immune function but these data are inconsistent. We
investigated the profile of markers of immune function (including
novel markers) in CFS/ME patients.

Methods
We included 95 CFS/ME patients and 50 healthy controls. All
participants were assessed on natural killer (NK) and CD8+T cell
cytotoxic activities, Th1 and Th2 cytokine profile of CD4+T cells,
expression of vasoactive intestinal peptide receptor 2 (VPACR2),
levels of NK phenotypes (CD56bright and CD56dim) and regulatory T
cells expressing FoxP3 transcription factor.

Results
Compared to healthy individuals, CFS/ME patients displayed significant
increases in IL-10, IFN-gamma, TNF-alpha, CD4+CD25+ T cells, FoxP3 and
VPACR2 expression. Cytotoxic activity of NK and CD8+T cells and NK
phenotypes, in particular the CD56bright NK cells were significantly
decreased in CFS/ME patients. Additionally granzyme A and granzyme K
expression were reduced while expression levels of perforin were
significantly increased in the CFS/ME population relative to the
control population. These data suggest significant dysregulation of
the immune system in CFS/ME patients.

Conclusions
Our study found immunological abnormalities which may serve as
biomarkers in CFS/ME patients with potential for an application as a
diagnostic tool.

1 comment:

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