Tuesday, May 17, 2011

Xenotropic Murine Leukemia Virus - Distinct Inflammatory Signature

Xenotropic Murine Leukemia Virus-related Virus-associated
Chronic Fatigue Syndrome Reveals a Distinct Inflammatory Signature


The recent identification of xenotropic murine leukemia virus-related virus (XMRV) in the blood of patients with chronic fatigue syndrome (CFS) establishes that a retrovirus may play a role in the pathology in this disease. Knowledge of the immune response might lead to a better understanding of the role XMRV plays in this syndrome. Our objective was to investigate the cytokine and chemokine response in XMRV-associated CFS. The purpose of this study was to evaluate differences in cytokine and chemokine profiles between XMRV-infected CFS patients and healthy control subjects. This study clearly demonstrates XMRV-infected CFS patients display an inflammatory cytokine and chemokine signature that distinguishes them from healthy control subjects. The availability of complete viral genome sequences from many symptomatic and asymptomatic individuals may lead to a greater understanding as to why some individuals manifest symptoms of neuroimmune disease while oth ers do not.
Vincent C Lombardi, Judy A Mikovits et al, in vivo 25: 307-314 (2011)
Related Links:
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Presence Of Murine Leukemia Virus Found In Chronic Fatigue Syndrome Patients
FDA Press Release
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Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors (FULL TEXT)
Shyh-Ching Lo, Harvey J. Alter et al PNAS
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Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome

Judy A. Mikovits et al, 10.1126/science.1179052, Science Express


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