Datum: 21 december 2010
Statement from the Whittemore Peterson Institute regarding
Retrovirology December 20,2010by Whittemore Peterson
Institute on Tuesday, 21 December 2010 at 04:13
The Lombardi et al. and Lo et al. studies were done using
four different methods of detection. They were not simply
PCR experiments, as were the studies by McClure et al. and
others who have recently reported their difficulties with
contamination. Experienced researchers such as Mikovits,
Lombardi, Lo and their collaborators understand the
limitations of PCR technology, especially the possibility
of sample contamination. As a result, we and Lo et al.
conducted rigorous studies to prevent and rule out any
possibility that the results reported were from contamination.
In addition to the use of PCR methodology, the Lombardi team
used two other scientific techniques to determine whether,
in fact, we had found new retroviruses in human blood
samples. We identified a human antibody response to a gamma
retroviral infection and we demonstrated that live gamma
retrovirus isolated from human blood could infect human
cells in culture. These scientific findings cannot be
explained by contamination with mouse cells, mouse DNA or
XMRV-related virus-contaminated human tumor cells. No mouse
cell lines and none of the human cell lines reported today
by Hue et al. to contain XMRV were ever cultured in the
WPI lab where our PCR experiments were performed. Humans
cannot make antibodies to viruses related to murine leukemia
viruses unless they have been exposed to virus proteins.
Therefore, recent publications regarding PCR contamination
do not change the conclusions of the Lombardi et al. and Lo
et al. studies that concluded that patients with ME/CFS are
infected with human gammaretroviruses. We have never claimed
that CFS was caused by XMRV, only that CFS patients possess
antibodies to XMRV related proteins and harbor infectious
XMRV, which integrates into human chromosomes and thus is a
human infection of as yet unknown pathogenic potential.
"The coauthors stand by the conclusions of Lombardi et al. Nothing that has been published to date refutes our data."
Judy A. Mikovits
(c) 2010 Whittemore Peterson Institute