cytokine activity in chronic fatigue syndrome'
White AT, Light AR, Hughen RW, Bateman L, Martins TB, Hill HR, Light KC.
Department of Exercise and Sport Science, University of Utah, Salt
Lake City, Utah, USA.
Psychophysiology. 2010 Mar 4. [Epub ahead of print]
Chronic fatigue syndrome (CFS) patients often report symptom flare
(SF) for >24 h after moderate exercise (post-ex). We hypothesized that
SF is linked to increases in circulating cytokines and CD40 Ligand
(CD40L). In 19 CFS patients and 17 controls, mental and physical
fatigue and pain symptom ratings were obtained together with serum for
11 cytokines and CD40L before and at 0.5, 8, 24, and 48 h post-ex.
Before exercise, CFS had lower CD40L (p<.05) but similar cytokines
versus controls. In subgroups based on SF at 48 h, high SF patients
(n=11) increased in IL-1beta, IL-12, IL-6, IL-8, IL-10, and IL-13
(p<.05) 8 h post-ex. Low SF patients (n=8) showed post-ex decreases in
IL-10, IL-13, and CD40L, and controls decreased in IL-10, CD40L, and
TNFalpha (p<.05). Thus, in CFS, cytokine activity may vary directly
with SF, which may explain prior inconsistent findings.