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Neuro Endocrinol Lett.;30(4).
Coenzyme Q10 deficiency in myalgic
encephalomyelitis / chronic fatigue
syndrome (ME/CFS) is related to fatigue,
autonomic and neurocognitive symptoms
and is another risk factor explaining the
early mortality in ME/CFS due to cardi.
Maes M, Mihaylova I, Kubera M, Uytterhoeven M,
Vrydags N, Bosmans E.
Maes Clinics, Antwerp, Belgium. email@example.com.
Myalgic encephalomyelitis / chronic fatigue syndrome
(ME/CFS) is a medical illness characterized by
disorders in inflammatory and oxidative and
nitrosative (IO&NS) pathways.
This paper examines the role of Coenzyme Q10
(CoQ10), a mitochondrial nutrient which acts as an
essential cofactor for the production of ATP in
mitochondria and which displays significant
Plasma CoQ10 has been assayed in 58 patients with
ME/CFS and in 22 normal controls; the relationships
between CoQ10 and the severity of ME/CFS as
measured by means of the FibroFatigue (FF) scale
Plasma CoQ10 was significantly (p=0.00001) lower in
ME/CFS patients than in normal controls. Up to
44.8% of patients with ME/CFS had values beneath
the lowest plasma CoQ10 value detected in the
normal controls, i.e. 490 mug/L.
In ME/CFS, there were significant and inverse
relationships between CoQ10 and the total score on
the FF scale, fatigue and autonomic symptoms.
Patients with very low CoQ10 (<390 mug/L) suffered
significantly more from concentration and memory
disturbances. The results show that lowered levels of
CoQ10 play a role in the pathophysiology of ME/CFS
and that symptoms, such as fatigue, and autonomic
and neurocognitive symptoms may be caused by
Our results suggest that patients with ME/CFS would
benefit from CoQ10 supplementation in order to
normalize the low CoQ10 syndrome and the IO&NS
The findings that lower CoQ10 is an independent
predictor of chronic heart failure (CHF) and mortality
due to CHF may explain previous reports that the
mean age of ME/CFS patients dying from CHF is 25
years younger than the age of those dying from CHF
in the general population.
Since statins significantly decrease plasma CoQ10,
ME/CFS should be regarded as a relative
contraindication for treatment with statins without
PMID: 20010505 [PubMed - as supplied by publisher]