Wednesday, January 6, 2010

British XMRV study shot down

Background: a study performed in England has supposedly found that CFS patients don't have XMRV, but was immediately questioned whether these were True CFS patients or psychiatric patients who were misdiagnosed with CFS because they have fatigue.  www.CFIDS.org promptly published a rebuttal by their medical director, and here's another:
 
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Invest in ME

Invest in ME Statement on BBC NEWS Article "Research finds no proof that a virus is the cause of ME"

6th January 2010

The perennial problem of trials such as this from
ICL and those funded by the Medical Research
Council is that they do not use well defined patient
cohorts which can negate the research results.

To replicate a research study the patient samples
used and the methodology have to be the same
and in this case it appears that there are
differences in both compared to the study
published online 8 October, 2009 by the Science
magazine.

The organisations in USA who discovered the
XMRV retrovirus used the Canadian Guidelines to
select patients for their research and  Invest in ME
feel the Canadian Guidelines should be used for all
research.

Those who portray ME as a somatoform illness
are fully aware that using patients who do not fit
strict selection criteria will obviously skew results.
We therefore have serious doubts about the the
results of the ICL research.

If the correct patient cohorts are not participating
in the trials or different methods are used then
this will affect the results.

The result of finding no sign of XMRV would point
to a different methodology to that used in the
research published by the Science magazine 3.7%
of controls tested positive.

The work performed by the Whittemore-Peterson
Institute (WPI) and the National Cancer Institute
and the Cleveland Clinic is of the highest quality
and has been validated by Science magazine.

Much more research is underway and the results
from the first XMRV replication trials such as these
from ICL prove little.

People with ME and their families should expect
these "false" results to be publicised early,
especially as ME has been ignored by the
government and research organisations for
generations.
However, the new XMRV research
has changed the landscape for good and patients
and carers can look forward to a new era of
ME/CFS research based on the biomedical basis
for the illness.

Proper science is now finally being performed.

Those who have delayed or stopped high quality
biomedical research into ME from being performed
in the past, and those who continue to downplay
the significance of the new research from WPI,
will not be in a position to continue this denial for
much longer.

The WPI have promised more exciting news which
we can expect to hear at the forthcoming 5th
Invest in ME International ME/CFS Conference on
24th May in London.


Invest in ME remain convinced that the WPI
research is of monumental importance to the
future of research into ME and we look forward to
the future and the momentum in biomedical
research into ME which the XMRV research has
generated.


Invest in ME
Registered UK Charity Nr. 1114035
www.investinme.org
PO BOX 561, Eastleigh SO50 0GQ


A New Era in ME/CFS Research

5th International ME/CFS Conference
24th May 2010 Westminster, London
http://tinyurl.com/ykdoqkc

Support ME Awareness - Invest in ME


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