Wednesday, July 29, 2009

Enterovirus and CFS

This article is in the most recent Journal of IiME and is really neat.
It talks about the mechanisms used by enteroviruses to persist long
term in a human host in the apparent absence of infectious virus
particles. It also mentions Chia's CFS-enterovirus work. It starts on
page 23, it wouldn't allow copy and pasting for reposting here.


Journal of IiME - Volume 3 Issue 1 -

'Human Enteroviruses and Chronic Infectious Disease'
Steven Tracy and Nora M. Chapman

Enterovirus Research Laboratory, Department of Pathology and
Microbiology, University of Nebraska Medical Center, 986495 Nebraska
Medical Center, Omaha, NE, 68198-6495, USA.


Most of what is known about human enteroviruses(HEV) has been derived
from the study of the polioviruses, the HEV responsible for
poliomyelitis. The HEV are generally not thought to persist for long
periods in the host: an acute, sometimes nasty, infection is rapidly
eradicated by the host's serotype-specific adaptive immune response.

Our discovery that the commonly encountered HEV, the group B
coxsackieviruses(CVB), can naturally delete sequence from the 5' end
of the RNA genome and that this deletional mechanism results in
long-term viral persistence, in the face of the adaptive immune
response, has substantially altered this view.

This previously unknown and unsuspected aspect of enterovirus
replication provides an explanation for previous reports of
enteroviral RNA detected in diseased tissue in the apparent absence of
infectious virus particles.

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