Wednesday, June 17, 2009

Revised methylation protocol

Thanks, Rich!
For anyone who is currently following or is considering the Simplified Treatment Approach for lifting the methylation cycle block and restoring the glutathione levels in CFS, I want to advise you of a change in the protocol.  Metagenics has changed the formulation of their product Intrinsi/B12/folate, which was included in the original protocol, so that it no longer contains folinic acid (5-formyl tetrahydrofolate).  Therefore, I am now recommending that another Metagenics product, Actifolate, be substituted in the protocol, at the same dosage.

Here is a description of the revised protocol:

(Extracted from the full treatment program
developed by Amy Yasko, Ph.D., N.D.
which is used primarily in treating autism [1])


FolaPro      [2]:  ¼ tablet (200mcg) daily

Actifolate       [3]:  ¼ tablet daily

General 20 Vitamin Neurological Health Formula [4]: 
     start with ¼ tablet and work up dosage as tolerated to 2 tablets daily

Phosphatidyl Serine Complex [5]:  1 softgel capsule daily

Activated B12 Guard [6]:  1 sublingual lozenge daily 

      All these supplements can be obtained from ,
or all but the third one can be obtained from other sources.

     The first two supplement tablets are
difficult to break into quarters. We recommend that you obtain (from any
pharmacy) a good-quality pill splitter to assist with this process. They can,
alternatively, be crushed into powders, which are then separated on a flat
surface using a knife or single-edged razor blade, and the powders can be mixed
together.  They can be taken orally with water, with or without food.

     These supplements
can make some patients sleepy, so in those cases they take them at bedtime.  They can be taken at any time of day, with or without food.  

     GO SLOWLY.  As the methylation cycle block is lifted,
toxins are released and processed by the body, and this can lead to an
exacerbation of symptoms. IF THIS HAPPENS, try smaller doses, every other
day.  SLOWLY work up to the full dosages.

     Although this treatment approach consists only of nonprescription nutritional supplements, a
few patients have reported adverse effects while on it.  Therefore, it is necessary that patients be supervised
by physicians while receiving this treatment.

[1]  Yasko, Amy, and Gordon, Garry, The Puzzle of Autism, Matrix Development Publishing, Payson, AZ, 2006, p. 49.

[2]  FolaPro is a registered trademark of Metagenics, Inc.

[3]  Actifolate is a registered trademark of Metagenics, Inc.

[4]  General Vitamin Neurological Health Formula is formulated and supplied by Holistic Health Consultants LLC.

[5] Phosphatidyl Serine Complex is a product of Vitamin Discount Center.

[6] Activated B12 Guard is a registered trademark of Perque LLC.

Rich Van Konynenburg, Ph.D.


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