ME: 'Invisible disease' is now easier to read
Image caption: "The stigma associated with the disease can sometimes be as
much of a problem as the symptoms."
Last Updated: 12:01am GMT 18/03/2008
A simple blood test may revolutionise the way we treat patients with ME,
reports Bob Ward
British researchers are close to developing, for the first time, a blood
test and potential drug treatments for myalgic encephalomyelitis (ME), also
known as chronic fatigue syndrome (CFS), following groundbreaking work on
its genetic origins.
ME/CFS affects about one in 200 people, and women sufferers outnumber men by
six to one. It causes a constant feeling of extreme exhaustion and malaise
for more than six months, along with sleep abnormalities, memory and
concentration difficulties and a great deal of pain.
In its most extreme form, the disease leaves sufferers bed-ridden and can
even be fatal.
But patients now have new hope, thanks to research published in the Journal
of Clinical Pathology by Dr Jonathan Kerr of St George's University of
London and his colleagues.
They have identified 88 genes that produce different levels of proteins and other molecules in ME/CFS sufferers compared with the rest of the population.
Dr Kerr's team carried out a complex analysis of the records of 55 patients
and found that they could be divided into seven sub-types according to the
specific gene combinations found in their white blood cells, and the
severity of their symptoms.
The most acutely affected patients had 71 of the 88 gene abnormalities.
The results of this work should allow better understanding of the causes and
development of the disease. Many of the genes are known to be affected when a person contracts a virus, a factor which is believed to trigger many cases of ME/CFS.
Importantly, the researchers also recognised that five of the 88 genes are
targeted by drugs which are already used to treat other diseases.
The team is now investigating whether the faulty genes produce abnormal
levels of proteins that can be detected as minute quantities of "biomarkers"
in the blood of patients.
"If proven to be sensitive and specific indicators of the illness, the
discovery of protein biomarkers could lead to the development of a
diagnostic test for ME/CFS, which would revolutionise our approach to this
disease," explains Dr Kerr.
He will present his results at a conference on ME/CFS biomedical research in
Cambridge in May.
The research may even lead to a change in attitudes to the disease, often trivialised as "yuppie flu".
Sarah, 31, who was diagnosed with ME/CFS two years ago, says: "The stigma
associated with the disease can sometimes be as much of a problem as the
"Some think that it is 'all in the mind' and can be cured by a good night's
sleep. It can be difficult to get friends and work colleagues to understand
just how difficult it is to live with a disease that is so debilitating but
Attitudes among funders of medical research also need to change, says Dr Neil Abbot, operations director at the charity ME Research UK. "Studies on the psychological aspects of ME/CFS seem to have vacuumed up attention and funding at the expense of hard-core biomedical studies," he says.
"Most of the £3 million spent by the Medical Research Council on the illness
in the last six years has gone towards projects on the psychological
management of the disease, while there is evidence that around 30
applications, some from established biomedical research groups, have not
The work carried out by Dr Kerr and his colleagues is funded by a small
charity, the CFS Research Foundation, which was set up in 1993 by a group of
doctors and scientists who were concerned about the direction and quality of
work on the disease.
Its director, Anne Faulkner, is optimistic about the search for a cure: "We
believe that this disease can and will be conquered, but it will need the
dedicated work of distinguished research scientists and the determination of
people in the community to bring this about."
Bob Ward has donated the fee for this article to the CFS Research
Foundation (www.cfsrf.com ) and ME Research UK (www.meresearch.org.uk ). He is
former winner of the Bayer/Telegraph science writer award, judged by a panel
that includes Sir David Attenborough and Adam Hart-Davis, which is now open
to 15-year-olds too. The closing date is March 31. See science-writer.co.uk
* * *
One more nail in the coffin of those crackpots who call us lazy and crazy because they cannot accept the notion that this is a serious physical ailment caused by a virus and not just a personality flaw.
Go ahead, have one last laugh at our expense, because when this is proven it's going to be those people who are called crazy for denying the reality for so long in the face of 5000+ research studies proving objective medical abnormalities in True CFS patients. The stupidity and stubbornness of the detractors always amazes me ... they can't accept that maybe they were wrong.