Wednesday, May 31, 2006


U.S. Newswire

Potential Animal (Zoonotic) Virus Identified in Patients with Chronic Fatigue
Syndrome, Multiple Sclerosis and Epilepsy

5/31/2006 12:00:00 PM

To: National Desk

Contact: Gail Kansky of the National CFIDS Foundation, 781-449-3535 or
[email protected]

NEEDHAM, Mass., May 31 /U.S. Newswire/ -- Recent independent scientific
research funded by the National CFIDS Foundation, Inc. (NCF) of Needham, MA
provided preliminary confirmation of a new virus identified in patients with
Chronic Fatigue Syndrome. The Foundation's medical research dovetails with that
completed to date by Cryptic Afflictions, LLC (1), a private company.

Dr. Steven J. Robbins, virologist and Chief Executive Officer of Cryptic
Afflictions, LLC has discovered a major neuropathogen identified as an RNA
virus designated as Cryptovirus. Substantial clinical and molecular evidence
indicates that this virus is involved in the development of neurological
disorders that include Chronic Fatigue Syndrome (CFS), also known as Myalgic
Encephalomyelitis (M.E.) by the World Health Organization, Multiple Sclerosis
(M.S.) and Idiopathic Epilepsy of unknown cause.

According to the company, "This previously undetected virus appears to be of
significant importance to researchers looking for a cure to Multiple Sclerosis
and many other neurological illnesses. Antibodies to the newly discovered virus
were found in the cerebrospinal fluid and blood of over 90 percent of the
patients tested with Multiple Sclerosis. It is believed that this newly
discovered virus may prove to be responsible for a host of neurological
disorders. Tests are currently being prepared for tissue samples of lesions
within the brains of patients with Multiple Sclerosis. This will be the final
round of tests before approaching the FDA for approval of the diagnostic

Dr. Robbins' evidence includes the presence of virus-specific antibodies in the
serum and cerebrospinal fluid of patients suffering from these disorders, the
ability of the virus to cause virtually identical disease in
experimentally-infected animals, and nucleotide sequence data that indicates
that the virus is pandemic and represents a single virus species much like

A recently published medical journal article suggests that Cryptovirus is most
similiar to Parainfluenza Virus-5, a rubulavirus in the paramyxovirus family.
Another rubulavirus related to Cryptovirus and Parainfluenza Virus-5, that has
gained national attention for its large outbreak, is the mumps virus.
Rubulavirus infections have been associated with encephalitis, meningitis,
orchitis, inflammation of the testicles or ovaries, spontaneous abortion, and

The NCF has conducted its own preliminary research into the potential role of
Cryptovirus and Parainfluenza Virus-5 in Chronic Fatigue Syndrome. Professor
Alan Cocchetto, Medical Director for the Foundation stated, "Our own funded
research first confirmed the lack of a vital protein, known as Stat-1, in the
blood of patients with Chronic Fatigue Syndrome. Stat-1 plays an indispensable
role in immunity. Without this protein, patients are unable to effectively
fight viral and bacterial infections. Thus, the next logical question to be
answered was 'Could a virus be causing this Stat-1 depletion?' " Cocchetto
continued, "Parainfluenza Virus-5 is a virus that had to be seriously
considered as a possible piece of this medical puzzle because it directly
targets and destroys the Stat-1 protein." Gail Kansky, President of the NCF
stated, "Once we determined the status of Stat-1 in patient blood samples, we
knew that we had to look for possible evidence of Parainfluenza Virus-5
infection. It was during this phase of our own research that we actually
learned of Dr. Steven Robbins' discovery of Cryptovirus specific antibody
reactivity in patients with CFS." Dr. Robbins had tested fifty- six serum
specimens from patients who had been diagnosed with CFS along with eleven
matching cerebrospinal fluid samples obtained from physicians in Brisbane and
Southeast Queensland. Dr. Robbins had determined that 96 percent of the blood
samples and 91 percent of the spinal fluid samples tested positively for
Cryptovirus specific antibodies in these CFS patients.

The National CFIDS Foundation's own research began to dovetail with that of Dr.
Robbins. Scientists funded by the Foundation performed numerous tests for
Parainfluenza Virus-5 that included antibody as well as PCR specific probes.
Antibody testing provided some initial hints, however a PCR specific probe
picked up the infection in a former patient of David S. Bell, M.D. and Paul R.
Cheney, Ph.D., M.D., both considered well known specialists in the field of
Chronic Fatigue Syndrome. Kansky commented, "Though our funded research
continues in diagnostic testing, our findings have served to highlight the
important work of

Dr. Robbins and the role of Cryptovirus and Parainfluenza Virus-5 infection in

NCF scientists utilized the NIH Genbank database to find the nucleotide
sequence for a specific viral protein of Cryptovirus that matched 100 percent
to the porcine (swine) strain of Parainfluenza Virus-5 known as the SER strain.
In 1994, scientists at Bayer AG in Germany first isolated the SER strain from
swine with Porcine Reproductive and Respiratory Syndrome. "This may represent a
zoonotic process since zoonotic viruses are those that can be transmitted
between animals and people" stated Cocchetto. Kansky commented, "Here we have
what appears to be the same viral strain of Parainfluenza Virus-5 on two
continents and in two different populations, swine and humans. Given that the
NCF found Parainfluenza Virus-5 in one CFS patient in the United States
certainly raises the bar." The Foundation is currently funding further

The National Institutes of Health (NIH) has several ongoing grants in the
Parainfluenza Virus-5 field. Currently, however, there is only one U.S.
scientist specifically funded for research on the SER strain of Parainfluenza
Virus-5 by the NIH.


(1) "Limina Biotechnologies, Inc. is a recently formed subsidiary of Global
Medical Technologies, Inc. that was established for the purpose of merging
Cryptic Afflictions LLC and Global Medical Technologies, Inc. It is the intent
of management to spin off this newly formed corporation once the merger is
completed so Limina can raise capital through its own IPO," according to the
company's website,


Founded in 1997, the National CFIDS Foundation has grown to become the largest,
all-volunteer patient organization of its type in the United States. The
Foundation has no paid employees and is funded solely by individual donations
for the primary purpose to fund medical research into the cause and treatment
and/or cure of Chronic Fatigue Immune Dysfunction Syndrome (CFIDS/CFS).


/© 2006 U.S. Newswire 202-347-2770/